The Blood-Brain Barrier and Cancer: Transporters, Treatment, and Trojan Horses
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چکیده
منابع مشابه
The blood-brain barrier and cancer: transporters, treatment, and Trojan horses.
Despite scientific advances in understanding the causes and treatment of human malignancy, a persistent challenge facing basic and clinical investigators is how to adequately treat primary and metastatic brain tumors. The blood-brain barrier is a physiologic obstruction to the delivery of systemic chemotherapy to the brain parenchyma and central nervous system (CNS). A number of physiologic pro...
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The mammalian brain restricts the entrance of ions and solutes circulating in the bloodstream by two cellular barriers, namely, the blood-brain barrier (BBB) and bloodcerebrospinal fluid (CSF) barrier (Brightman et al., 1970; Ballabh, 2004). The BBB is built up by a monolayer of endothelial cells (ECs) lining the brain capillaries that restricts the movement of small polar molecules and macromo...
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The neuroprotective function of the blood-brain barrier (BBB) presents a major challenge for drug delivery to the central nervous system (CNS). Critical to this function, BBB membrane transporters include the ATP-binding cassette (ABC) transporters, which limit drug penetration across the BBB, and the less-well-studied solute carrier (SLC) transporters. In this work, expression profiling of 359...
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ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2007
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-06-2854